How the Zephyr Valve Works

The Zephyr Valve Helps Patients Breathe Easier and Have Less Shortness of Breath1

Hyperinflation is a devastating complication of emphysema, in which air becomes trapped in the lungs and breathing becomes very difficult.  Hyperinflation is associated with decreased exercise performance, decreased quality of life, increased COPD exacerbations, and increased mortality.

Source: Adapted from Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD)

The Zephyr Valve – A New Treatment Paradigm for Severe Emphysema

Oxygen Therapy, Corticosteroids, Bronchodilator

Pulmonary Rehabilitation

Zephyr Endobronchial Valves

Lung Volume Reduction Surgery

Lung Transplant


  • COPD medication – This may involve bronchodilator inhalers, oral steroids, antibiotics, or other prescription medications.
  • “Stop smoking” program – In order to benefit from minimally-invasive treatment options, the patient is required to stop smoking to receive treatment.
  • Pulmonary rehabilitation – You may refer your patient to therapy to help them exercise their lungs and learn how to breathe more efficiently.
  • Oxygen therapy – Emphysema reduces the amount of oxygen that can reach the patient’s bloodstream. You may prescribe oxygen therapy when medication is not doing enough for your patient.


  • Zephyr Endobronchial Valve – The Zephyr Valve is a device for the treatment of emphysema. It is not another prescription medication or surgery that requires cutting or incisions. Instead, the Zephyr Valve treatment is a bronchoscopic procedure that is clinically proven to help patients breathe easier, do more, and enjoy a better quality of life.1 Complications of the Zephyr Endobronchial Valve treatment can include but are not limited to pneumothorax, worsening of COPD symptoms, hemoptysis, pneumonia, dyspnea and, in rare cases, death.


  • Lung volume reduction surgery and bullectomy surgery – A surgeon will open the chest and cut out areas of damaged lung tissue, or large air spaces (bullae). It has been shown to improve patients’ breathing but has a risk of side effects and death.
  • Lung transplant – When the lungs are too damaged to benefit from surgery, certain patients may meet the criteria for lung transplantation surgery. If patients receive this treatment, they must take immune-suppressing medications for the rest of their lives. In addition, the transplant also carries high-risk complications such as organ rejection or death.

During this one-time bronchoscopic procedure, an average of four Zephyr Endobronchial Valves are placed in the airways to occlude the most diseased parts of the lungs. The Zephyr Valve allows trapped air to escape until the lobe is reduced in size.

Reducing hyperinflation and preventing air trapping in the treated lobe allows the healthier parts of the lung to expand and take in more air. Patients treated with the Zephyr Valve report improved breathing and the ability to go back to doing everyday tasks more easily.1

Zephyr Procedure

  • Zephyr Valves are implanted bronchoscopically under either general anesthesia or conscious sedation
  • On average, four Zephyr Valves are placed in segmental and subsegmental airways to completely occlude the target lobe with the goal of achieving target lobe volume reduction
  • Zephyr Valves can be removed through the bronchoscope if needed

Post-Procedure Care

Patients who receive Zephyr Valves should remain in the hospital for at least 3 nights to monitor for any side effects from the procedure.

Learn More About Benefits & Risks